The migration of Three Gorges inhabitants represents the largest scale in Chinese history, involving the largest population of migrants from the reservoir area. As a result, the migrants' original mode of production, living structure, social environment, and cultural practices have undergone profound changes, with similar impacts on local residents of such resettlement area. From an anthropological perspective, this paper focuses on the migrants from Wanzhou District of Chongqing to Guangdong to analyze the reasons behind the transformation and integration of social and economic structures in the migrants’ resettlement area by exploring the factors including historical, cultural and socio-economic dimensions, policy system, social support, and the migrants themselves through interviews with migrants, local residents, and local government authorities, as well as to discuss resource allocation, economic structure, and cultural structure during the migration process.