Corporate culture is an inexhaustible driving force for the survival and development of enterprises, and an important guarantee for the generation of sustainable value. In the post-epidemic period, the world's multipolarity, economic globalization, social informatization and cultural diversification are deeply integrated and developing, the change of global governance system and international order is accelerating, uncertainties are increasing, and traditional security and non-traditional security issues are complexly intertwined. The new economic situation has highlighted the important role of corporate culture in global economic development, and the corporate culture and corporate image of multinational companies are facing many new opportunities and challenges, which need to be reconstructed and effectively communicated. In the era of integrated media, big data, artificial intelligence and social media are changing people's learning, life and work, and information dissemination is digital, instant, interactive, shared, participatory, personalized and fragmented. The traditional "5W" communication model is changing with the continuous change of big data and fragmentation of information access. Communication is no longer a single medium, but a multi-media, multi-platform, multi-channel interconnection and interactive sharing. How do multinational companies promote cultural communication in the context of fusion media? Under the new situation of international communication, how can multinational companies solve cultural conflicts and realize cultural communication? Based on the neoclassical "structure-function theory", this study analyzes three research dimensions, including ontological structure, autogenous structure and external structure, and uses cross-cultural communication theory, use and satisfaction theory, mass communication, co-direction theory and organizational theory to study the cultural communication of multinational enterprises in the era of integrated media and analyze the current situation and shortcomings of multinational enterprises' cultural communication, with a view to laying a certain research foundation for building a new path of cross-cultural communication.